Ten commandments of enzymology, amended.

نویسنده

  • Arthur Kornberg
چکیده

Reflections on advances and retreats in biochemistry have, over the years, generated several maxims. The late Efraim Racker’s ‘don’t waste clean thinking on dirty enzymes’ has been one of the most durable. On the occasion of a lecture in Jerusalem a decade ago, I framed a list of the ten ‘best’ maxims as ‘commandments’, which were later published as a ‘Guest Commentary’ in the Journal of Bacteriology [1]. These ten commandments have been useful in discussions of papers and reviews, as well as ongoing work. One simply says ‘Commandment three’ or simply ‘five’ and there is generally no need to explain an emphatic judgment. When TIBS invited me to submit my current version of the commandments, I realized that after only three years since their publication, the list needed to be judged again to qualify as my ‘top ten’. The list is personal, and has been narrowed by my previous focus on DNA replication and my current one on inorganic polyphosphate. I hope this game of choosing a ‘top-ten’ will encourage others to try it and then compare their lists with mine and others’.

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عنوان ژورنال:
  • Trends in biochemical sciences

دوره 28 10  شماره 

صفحات  -

تاریخ انتشار 2003